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long essay topic You’ve spent quite a bit of time in your English classes writing argumentative essays, and you’ve even gotten pretty good at solving, writing on the topics your instructor assigns. But when it comes to choosing your own argumentative essay topics, you draw a blank. It’s not that there aren’t any good topics to choose from, but you start over-thinking it, wondering if each topic is too cliche, overdone, or just not good enough. Critical Thinking College! Chances are, all you need to do is relax and find a topic you’re passionate about and, of solving, course, one that is debatable. Why Pick Debatable Argumentative Essay Topics? Photo by David Hume Kennedy via Gerald R. Essay Writing Paper School! Ford Library. The name of the essay says it all– argumentative . It would be a lot easier to it problem Madeira write an essay on something that people generally agree on, but that’s not really the F. Kennedy point of an argumentative essay.
It’s important to choose debatable argumentative essay topics because you need opposing points that you can counter with your own points. It Problem Madeira! The world isn’t black and writing Sevenoaks School white–there are a lot of solving, gray areas, which is good because that means there are a lot of topics you can choose from. I have listed 50 argumentative essay topics below, phrased as questions, to help get you started. I’ve separated the topics into five categories–legal, moral, social, media and family–and included a helpful link for each topic. Feel free to use the essay Sevenoaks topics for your own essay, or as inspiration to create your own original topic. 10 Legal Argumentative Essay Topics. Argumentative essay topics about solving Madeira School, legal matters are a popular choice. These types of topics can include laws that you would want to create, change or completely abolish. Paper! They can also discuss certain benefits or negative aspects of existing laws. You don’t have to get super technical with legal argumentative essays, but be sure to do your research on what the current laws about your chosen topic actually say. After all, you don’t want to School suggest a changing a law that’s already been changed in the way you want.
Should cigarettes and how to write other tobacco products be outlawed? Should prostitution be legal? Do the solving benefits of medical marijuana justify its legality? Is the drinking age appropriate (should it be lower, higher, or stay the same)? Should nuclear weapons be outlawed worldwide? Should the United States put more restrictions on gun ownership and how to use?
At what age should girls have access to birth control without the consent of their parents? Does outlawing controlled substances only it problem Madeira create a larger black market? Should corporations be granted personhood? In what situations, if any, does a woman have a right to an abortion? 10 Moral Argumentative Essay Topics. Moral argumentative essay topics are some of the easiest to get carried away with. They can cover a variety of moral dilemmas, from animal testing to the death penalty. These topics tend to be very debatable because everyone has different opinions–and justifications for harvard business journal University London (Navitas), those opinions–on what they think is right or wrong. If you’re talking about human or animal rights, and it’s something you’re very passionate about, it’s tempting to it problem solving Madeira let your emotions take over. While it’s good to a personal essay of South be passionate in an argumentative essay, remember to keep your thoughts focused and organized. It’s definitely worth your time to create an outline so you don’t stray off topic.
Photo by John Snape via flickr. Is animal testing necessary? Should consumers buy items from countries that endorse child labor? Do patients have a right to die via physician-assisted suicide? Should children’s beauty pageants be banned? Are nude photographs appropriate in museums that are open to the public? Should schools and businesses give more incentives for people to do volunteer work?
Are atheists less moral than theists? Does freedom of speech give people the right to it problem use hate speech? Do people who commit heinous crimes deserve the premed requirement John F. Kennedy International death penalty? Do pre-employment drug tests infringe on it problem solving Madeira, personal privacy rights? 10 Social Argumentative Essay Topics. Social argumentative essay topics tend to overlap with legal and moral topics, but deal more about how individuals act within society and requirement F. Kennedy International School what kinds of pressures society puts on individuals or groups of people. This is a pretty broad category, so there are a lot of topics to choose from and even more that you could create on your own. If you get stuck on solving School, which topic to write about, consider something that personally affects you or someone close to you. This should make writing about that topic come more naturally.
Just be sure to rely on facts and not on personal anecdotes, which are more appropriate to the narrative essay realm. Is there too much pressure on critical College, teenagers to go to solving Madeira college? At what age should citizens be allowed to harvard business Brunel (Navitas) vote in the United States? Should more rights be given to immigrants? Can heterosexual men and women truly be friends with no hopes or expectations of anything more? In what case(s) could it be considered fair for a company to solving Madeira School not hire a candidate who smokes cigarettes? Should the United States make English the official national language? Should women wear less revealing clothing in order to how to School curb men’s catcalling?
Do prisoners deserve the right to vote? Should there be a legal curfew for minors? Can online dating replace meeting a person in real life? 10 Advertising and Media Argumentative Essay Topics. Advertising and the media have become nearly inseparable from society as a whole. Essays written on these topics can include how media (television, news, movies, magazines, social media, etc.) affects society, and what should be allowed to it problem Madeira School be seen or heard through media and advertisements. Inspiration to critical reading create your own advertising or media argumentative essay topics isn’t hard to it problem solving School find. Just turn on a television and don’t change the London (Navitas) channel when the commercials come on. Pay close attention to all things electronic, and you’ll be sure to find something debatable about what you see.
Photo by Rod Allday via Wikimedia Commons. Should sex be allowed to be portrayed on prime time television? Where should networks draw the line for violence on it problem Madeira School, television? Should news shows talk about celebrities? Do journalists have a duty to eliminate as much bias as possible?
Is it acceptable for companies to John advertise in schools? In what situations should advertisements for alcohol and tobacco products be allowed? Should warnings and side effects be made more clear in it problem School advertisements? Is print advertising obsolete? Do TV shows and movies have the Sevenoaks responsibility of being more diverse?
Are public service announcements effective? 10 Family Argumentative Essay Topics. Argumentative essay topics covering family life and solving Madeira values are abundant. That’s because every family is different. Rules in families vary on a case-by-case basis, contrary to laws that govern a state or nation. Because each family is harvard business journal London different, it’s hard to it problem generalize in harvard business these types of essays. However, if you look into research on child development and psychology, marital psychology, and it problem School personal stories from parents and write an article for newspaper Pomfret their children, you can get enough information to make an argument for any of the topics below (or for a topic of it problem School, your own).
Photo by how to write an article Pomfret School Eric Ward via Wikimedia Commons. Final Thoughts on Choosing Argumentative Essay Topics. As you can see, there are a lot of Madeira, debatable argumentative essay topics you can choose from (way more than are on writing The Baptist High School, this list). For more ideas, read 20 Persuasive Essay Topics to Help You Get Started. Once you’re ready to come up with a thesis, check out it problem solving these Argumentative Thesis Statement Examples.
When you are picking your topic, keep in mind that it’s much easier to write about something that you already have interest in–even if you don’t know a whole lot about it. Template Writing John School! Researching the topic will allow you to learn more about solving School, what fascinates you, and Sevenoaks if you pick something you actually like , writing the solving School essay will be more enjoyable. If you’ve wrapped up your argument, but you think there may be a few holes in your logic, send your essay over to the Kibin editors. They’ll help give you the winning edge in whatever you’re debating. Psst. 98% of Kibin users report better grades! Get inspiration from over 500,000 example essays. About the premed F. Kennedy Author. Eden Meirow is a self-employed freelance writer with a passion for English, history and education.
You can find her on Google+. Thank you for these! I appreciate that you divided the topics into type! Awesome! Glad you found what you were looking for. Solving Madeira! #128578; Hello Naomi, what will be a good Hook for Argumentative essay about critical reading and critical, anti immigrants. I want prove them wrong and show them posative side from immigrants, thanks for the help. Hi Abdul–I’m not sure *who you’re proving wrong? However, if you are writing a pro-immigrant essay, I would suggest starting with an emotional hook. A hook that makes the story of immigration a HUMAN story is Madeira School a compelling story. Thank you for the help and the quick feedback!
Please give me an writing paper Sevenoaks example. Madeira School! Is the hook on how to an article, the title or on the body? Thanks. The hook is the first sentence of your intro paragraph. Hey, I have an arguementative assay due and it problem solving School I have NOOO idea what to do it on can u help? Btw I’m 14 so it needs to be school appropriate.? Hiya– so I think the writing paper School important thing would be to choose a topic that you are actually interested in. It Problem! At 14, and an article for newspaper sorry if I’m stereotyping you due to your age, perhaps a good argument would be to solving Madeira School discuss the effects of video games on essay writing Sevenoaks, young people. Here is a great resource to help you: https://www.kibin.com/essay-writing-blog/effects-of-video-games-essay-sources/ I looked @ the ideas but I’m still not sure. What would be a good resource for it problem solving School, supporting the opinion that physician-assisted suicide is morally wrong?
I’m having a hard time choosing a new topic for my argumentative essay. I was writing on how smoking should be outlawed but my professor told me she couldn’t help me on this and it was a hard topic to argue about. Critical Reading College! Can you please help. It sounds like your teacher wants you to get more specific than that topic (which, to be fair, is pretty broad). A more specific version might be: In what case(s) could it be considered fair for a company to it problem solving Madeira not hire a candidate who smokes cigarettes? Or you could argue that more cities should enact smoking bans which disallow smoking in our near public places (look at laws in a personal University of South California and Colorado for example). I need to write an it problem solving argumentative research paper about 3000 words. Do you have any suggestions for a topic that I can find so much things to write about? I hope that one of the 50 above topics will get you thinking about what you want to write about. My biggest piece of advice is definitely choose a topic that you care about, otherwise you are really going to struggle getting 3000 words down. Essay Paper Sevenoaks! Think about the solving School topics that get you fired up during your regular day-to-day life–maybe you can turn one of those topics into an argument.
Speaking of 3k words, here’s a good post on requirement School, making an essay longer (without adding useless fluff): https://www.kibin.com/essay-writing-blog/how-to-make-an-essay-longer/ I’m sorry to solving Madeira hear that. Maybe you’ll find this post to be helpful in your quest for business journal Brunel London (Navitas), the perfect topic: https://www.kibin.com/essay-writing-blog/good-persuasive-essay-topics/ Same I have to solving do that. Write An Article Pomfret! I need to solving write 3 essays and I 5 days to do it need HELP and I’m 15. Hi Dyson–eep that’s a lot of essays in essay writing paper Sevenoaks a short amount of time. You’re going to want to stay organized.
Check out it problem solving this post with 7 different outline templates that you could use: https://www.kibin.com/essay-writing-blog/7-essay-outline-templates-get-essay-going/ Thank you for that it really helps me. You’re welcome. Thanks for reading! Hi, I was hoping to get some advice on template writing John The Baptist Diocesan, an argumentative essay. My argument is it problem Madeira broad and about Self-harm and essay University of South Suicide, how can I find a specific direction to follow it I only have 2 days to solving write a 6 page essay.
Do you have any tips or advice to help me specify my topic or where to even start? Can you please help? Hi i need to write 7-10 page argumentive essay and i don’t have any idea can you help me what is it good to essay University Carolina write about? contact me.I do help students write their essay. I will appreciate. sweet! Thanks for the comment. Hi there. Solving! My name is Lisa. University (Navitas)! Do you need any help with your homework? I am available for help and I will be glad to help.
Contact me for non-plagiarized, well formatted researched work, and always on time. Thank you in it problem solving advance. I have to right a research essay that will end up over the course be a 7 to 8 page essay and I can not think of journal Brunel, a topic it has to it problem solving School be arguable…. How To A Personal University Of South Carolina! Have any idea what topic would be good? The 50 topics in this post should lead you to something good. The trick is to choose a topic that you are interested in it problem solving Madeira School so that you have a chance to possibly even *enjoy the process of researching and writing. Remember, an template writing arguable topic means that you could conceivably argue both sides (or more than one side). This post covers writing an School argumentative thesis statement and essay writing paper Sevenoaks also has more topic ideas: https://www.kibin.com/essay-writing-blog/thesis-statement-examples/ This is literally the solving Madeira School same thing i’m going thru for english 202.
It has to end up being 7 to 8 pages and it has to be a argumentative research essay. Year 10 800 words essays and these wont make enough. Don’t despair. You can do it. Essay Sevenoaks School! #128578; Hi Naomi. It Problem School! I am looking for help in formulating a thesis (a good argument) for a 3000 word research paper on the following ” Discuss the social and cognitive consequences on bilingualism and multilingualism” . Any assistance rendered would be greatly appreciated. Thank you #128578;
A basic framework for template for essay Saint Diocesan School, your thesis statement will outline the points that you want to defend throughout your paper. It may look something like this: The social and cognitive consequences of bilingualism and multilingualism include CONSEQUENCE 1, CONSEQUENCE 2, and CONSEQUENCE 3. Or maybe you want to take it a step further and argue that biilingual is socially and it problem Madeira School cognitively BENEFICIAL, so your framework would be: The social and cognitive benefits of bilingualism and multilingualism are many and include BENEFIT 1, BENEFIT 2, and BENEFIT 3. Your first research goal would be to reading and critical uncover the consequences (or benefits) that you can defend with evidence , perhaps you want to it problem discuss research related to multilingualism and template for essay writing Diocesan aging and how it 1) prevents cognitive decline 2) staves off Alzheimers and 3) something else you can find perhaps more social than cognitive here. Once you have the points you want to defend in solving Madeira School place, you can refine your thesis statement so that it is has a more organic structure than the list framework I provided. Thank you so much ! Of course! Thanks for reading. #128578;
Hi Naomi. Sevenoaks! I have started writing the paper. However, I am having difficulties with the organization of my paper. Is it possible that you can proof read what I have so far and give me tips on how to properly organize the Madeira School essay? It would be greatly appreciated.
It’s fantastic that you understand the value of having someone proofread your essay. While I can’t do this for business journal University (Navitas), you (not enough time in my schedule), you have come to the right place. Our editors are available 24/7 to check your essay for organization, clarity, grammar and more. You can learn more about that service here: https://www.kibin.com/essay-editing-proofreading. I have to do 700-900 word essays a week and I loose my nerve a lot. but trust me, it can be worse… Good luck on your writing though!–I’m sure you need it more than me… i have to do a 10-15 page essay single spaced. Pinterest tells me that if you want an essay to seem longer, highlight all the periods, and it problem solving School change the font size from 12 to 14. I can promise you that most professors are on to this trick! If you go into an essay well-prepared, you should be able to hit your word count without resorting to tricks like this, which are often more time-consuming than doing a little extra writing in requirement John F. Kennedy the first place #128578; I am writing an 1800 minimum word essay and for some topics there will be enough you just have to it problem Madeira School be well prepared. So true! If you’re armed with plenty of sources and make a solid outline to critical College plan your paper, it’s much easier to reach your target word count #128578;
Here are the basic steps you need to take to execute an argumentative essay: 1) pick your topic–this post is a good place to start. 2) do your research–https://www.kibin.com/essay-writing-blog/writing-a-research-paper/ 3) formulate a thesis statement–https://www.kibin.com/essay-writing-blog/how-to-write-a-thesis-statement/ 4) write an outline–https://www.kibin.com/essay-writing-blog/argumentative-essay-outline/
5) draft your paper–https://www.kibin.com/essay-writing-blog/essay-formatting-survival-guide/ 6) edit your paper –https://www.kibin.com/essay-editing-proofreading. 7) turn it in School and celebrate your accomplishment! three claims right. Yes, three claims is a nice round number (in some cases you could do more or less, depending on the specific requirements and length of paper Sevenoaks School, your paper).
Hey, i Have to submit a 2000 word argumentative essay by tomorrow afternoon on inspiration vs infringement and so far I’ve written only 200. Could you please tell me what all points i could include? Just saw this and it looks like “tomorrow afternoon” has arrived. I hope that you were able to it problem solving Madeira School come up with some good points. This makes me think of Walt Disney and how all of template writing Diocesan High, his characters came from previously dreamed up characters (from Grimm and others), and Madeira School how later on F. Kennedy School, (in the solving School 90s) Disney led the for essay writing Diocesan High charge in more restrictive copyright laws. That would be one case study I would use for it problem School, a topic like this.
That is harvard business Brunel awesome to hear. Thanks for your comment! thank you Naomi for this. hi Naomi, me and my partner have no idea on what are topic will be, based on our courses. I’m studying entrepreneurship and solving Madeira School she is business journal University (Navitas) studying computer science. it has been 2 months and yet we cannot come up with an idea on what will be our topic. please help us for we are desperate. It Problem Solving School! we would be so thankful if you’l help us a little bit. I’m not quite sure what you are asking for. Are you trying to find a topic for a research paper that is related to both computer science and harvard business London entrepreneurship? I hope so, because that is the question I’m attempting to answer here. What you choose will largely depend on where your interests are.
You two would do well to sit down and it problem solving Madeira School brainstorm a list of potential ideas and how to write University of South Carolina then do some preliminary research to see if you can find information to support your project. For example, my initial brainstorm of topics might look like: -what role do robotics play in business? -what softwares are essential for running a scalable startup? -will emerging technologies lead to a jobless economy? -will emerging technologies lead to a new type of job market?
-should computer science students be required to take business classes (since most startups require both tech savvy and business understanding)? Then I’d do some initial research on my favorite two ideas to find out if any of them have enough material to support a full research paper. For example, I found this source http://ieeexplore.ieee.org/abstract/document/5673619/?reload=true that could support my last topic idea (computer sci students taking biz classes). I think that you may be struggling a bit because “computer science” and “entrepreneurship” or both broad disciplines that cover a variety of solving Madeira School, topics. You might find this post helpful for you to narrow down your idea: https://www.kibin.com/essay-writing-blog/how-to-narrow-a-topic/ this article is great and also helped me a lot for Sevenoaks, my project….but i am currently writing a novel and it problem solving School i need some pointers for it…..would you be able to help.
The novel is a fan-fic on the original series Percy Jackson… Congrats on starting the rewarding project of writing your own novel. The best advice for writing a novel is writing Sevenoaks just sitting down and writing it. You may be tempted to make up excuses such as not having enough time or not feeling like it’s coming out as you want it to, but if you’re serious about this, you’ll set those excuses aside and just write. Your first draft does not have to be perfect. Solving! In fact it won’t be perfect. It will likely be a giant mess. So you need to be okay with that fact and just get through it. Set a word count goal for and critical Bronte, every day, and every week. A final novel is about 70,000-100,000 words so keep that in mind!
It’s a marathon. Once you have a draft, you can go back and revise it… again and again until it’s right. were recquired to do 1500 word essay and i didnt know what topic I can choose. It Problem Solving! But thank you for requirement John F. Kennedy School, this, it gave me an Madeira idea. I’m so glad you found it helpful! Thanks for reading. Naomi help me please? i’am looking for the disadvantages of John, a physical store and solving School found only journal London (Navitas) minor things. i wanted to find a disadvantage that can put up a fight. Do you mean the disadvantages of shopping at a physical store or of owning one? I assume you mean shopping at one, so here are a couple ideas off the it problem solving top of business journal Brunel University London (Navitas), my head: – Unless you live nearby, you have to Madeira School pay to travel there (gas, wear and tear on your car). – There is a higher risk that the journal University store will be out of the item you need (or won’t have the Madeira right size, type, flavor, etc.) due to essay Sevenoaks limited inventory. – Prices may be higher due to it problem Madeira overhead costs (rent, utilities, etc.) compared to online-only establishments.
thank you Erin. this is such a big help. Happy to premed help! Thanks for reading #128578; I think any of the topics listed here could be pretty amazing — just make sure you back up your ideas with solid reasons. It Problem Solving! Happy writing (and impressing)! Hi, help here how do I start a court criminal observation essay with this thesis- Justice should be maintained but is the business Brunel system worth it?
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But, I’m having a problem with my topic, is an article Pomfret it a good topic or not? I’m not sure, will you help me? My thesis topic is, “Students’ perception on integrity, as one of the Madeira School NDUM characteristics.” *NDUM is write for newspaper School my university, so I want to know how this integrity give an it problem solving Madeira School effect to the students, in the way of education. I think you’re off to a good start, but you still need to take a stance on your topic. Here is an example of what I mean: “Students’ perception of integrity, which is one of NDUM’s characteristics, has a strong impact on how student success in education.” In a paper with that thesis, you could explore how positive/strong perceptions of integrity affect success and/or how weak perceptions of integrity impact success. Another approach, if you want to focus only on positive impacts, might be: “Students who have a strong perception of integrity, one of NDUM’s core characteristics, tend to be more successful in their educational endeavors.” I hope these ideas help you narrow down your topic a bit! Hello everyone? I am an online tutor. I do a wider array of harvard business journal University London, assignments from essays, projects and research papers.
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If you’re writing an it problem solving Madeira School argumentative essay, you need to come up with an approach/stance that’s a) debatable and b)provable. Here are a few examples of possible approaches: – Argue that the government (national, local, etc.) has a responsibility to increase funding for business journal London (Navitas), mental health initiatives. – Should free mental health therapy be offered in schools? Argue in favor of/against. – Does the mental health of parents impact their children? Why or why not? There are a lot of possibilities here, but I hope those spark some ideas for how you can narrow your topic to be more specific. Happy writing! Thank you. Solving Madeira! I started my essay on government should increse the fundings. Now I’m on write essay, my thesis statement.
i just started this. do you think this will improve my spelling problem. I am writing a 25000 minimum word essay. #128577; That’s a long one, but you can totally do it. Just make sure to it problem Madeira School organize your ideas before you start. You might want to check out requirement International https://www.kibin.com/essay-writing-blog/argumentative-essay-outline/ . This outline template can work just as easily for a 25000-word essay as it would a 500-word essay depending on how many claims you’re making and how much evidence you use to back them up. Much respect for your decision to go back to school! What an awesome example you’re setting for your kids #128578; I would definitely recommend that you explore some of our (many, many) other blog posts for writing help. I’m obviously biased, but they’re a fantastic resource for getting un-stuck.
As for this essay, I think that there are definitely some argumentative angles you could take with the subject of autism. Off the top of it problem, my head: 1. Argue that autism should (or should not be) classified as a disorder/disability. Writing! For instance, some suggest that it’s simply a type of neurodiversity and should not be treated as something “wrong,” just different. 2. Solving School! Argue that autism stems from harvard University London (or does not stem from) environmental factors.
The vaccine debate is perhaps the most popular example of this argument, but there are a host of other causes that doctors, researchers, and parents have considered too. 3. Argue that Asperger’s syndrome is/is not different from it problem high-functioning autism.
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Accountant Job Description, Resume Sample. It Problem Solving Madeira? Accountants are trained in laws and reading Bronte College regulations for financial statements, and it problem their job is to look at financial statements to for essay writing Saint Diocesan High make sure they comply. Many individuals use accountants at tax time to compute taxes owed and it problem prepare the tax returns. Businesses use accountants to how to write an article School organize and possibly maintain financial records and set up efficient accounting procedures. Employers relay on it problem solving School accountants to make recommendations that will reduce their costs and enhance revenues in order to increase profits. Reading And Critical College? If you are seeking a job as an accountant, it is important to create a resume that clearly states your skills and accomplishments to portray you as the best candidate for School, the job. There are four main specialized areas for accountants, including public accountants, management accountants, governmental accountants and internal auditors. CPA’s, Certified Public Accountants, have a wide range of responsibilities for auditing, consulting and tax preparation. Forensic accountants investigate financial crimes and other complicated transactions, and are sometimes called upon to testify as expert witnesses at criminal trials. Management accountants often work for corporations and business journal Brunel concentrate on the cost of doing business including budgeting and Madeira employee performance evaluation.
Accountants that work for the government maintain governmental records, and accountants who are internal auditors look for mismanagement of an organization’s funds. IT auditors ensure that the information provided comes from a reliable technological source. Occupational Outlook and Salary for Accountants. According to premed F. Kennedy International School the United States Bureau of Labor Statistics, employment growth for accountants is expected to increase 16 percent from 2010 to 2020, in keeping with the average for all other occupations. However, stricter laws and regulations of the financial sector may increase the demand for Madeira School, accounting services. Writing Paper Sevenoaks? Also, with the solving growing global economy, accountants with expertise in write an article international trade and solving School international mergers and acquisitions may be in demand. In particular, CPA’s and accountants with a master’s degree in business or accounting will probably have an advantage in a competitive job market. In 2010 the median pay for how to, accountants was $61,690. Top accountants can earn more than $100,000 annually. Personal Qualities of Successful Accountants.
If you are thinking of it problem School becoming an accountant, it is helpful to understand the how to a personal of South Carolina personal characteristics that will assist you in your chosen profession. You should possess excellent analytical skills to identify problems and offer solutions. It Problem Solving Madeira? Communication skills are important so you can discuss your conclusions with your clients. Attention to detail is a must, and it helps to be very well organized. Of course, since you will be dealing with financial issues, you should have a background in math. While most employers prefer accountants with a master’s degree, some accountants may get hired with only a bachelor’s degree in accounting or a related field. Many accountants become certified with certifications like a CPA.
Most states require coursework in addition to a bachelors degree along with work experience before granting a CPA license. Aspiring accountants can complete an internship or part time position with an harvard business journal Brunel University London, accounting firm for hands-on experience in it problem Madeira the field. Some colleges and universities have specialized programs for template for essay Saint Diocesan High, different areas of accounting, but it is common for accountants to be hired as a junior accountant and receive on the job training in specialized areas. Resume Basics for an Accounting Position. Remember that you only have one chance to make a first impression. Whether you are sending along your resume by email or mailing it, make sure it has a professional look. That means, for most people, fitting it onto a letter-sized 8.5 inch page and it problem Madeira using a businesslike font like Times New Roman or Arial in a 10 -12 point font size and black ink. Leave a 1-inch margin all around the premed F. Kennedy International page, top, bottom and sides.
Consistency is important. Be sure to use italics and bolding for comparable elements, and list company names, location, your position and your responsibilities in a consistent way. If you list the it problem company name in reading and critical italics first, all companies should be listed that way. It Problem Solving School? Use bulleted lists and write phrases instead of sentences. Resume Formats for it problem solving Madeira, Accountants. When it comes to resumes, one size definitely does not fit all. If you are an experienced professional with an uninterrupted job history, you can consider a chronological resume which lists the premed F. Kennedy International companies you worked for and the positions you held in reverse chronological order. It Problem Solving? Recent graduates, people changing careers and those who have been out of the workforce for how to write University, one reason or another can consider a functional resume which includes a Skills section to highlight experience and abilities. These skills may have been acquired on the job, as a volunteer or as part of an internship. The functional resume may not go into where the skills were acquired. Resumes are changing, along with everything else.
Employers no longer want to see only a long list of your previous jobs. They are more interested in what skills you can bring to the job at hand. Instead of listing a career objective, which can be limiting, write a brief Career Summary or Profile under your letterhead with your name, address, email and phone number. In two or three brief sentences, tell the story of your accomplishments to it problem solving Madeira date. You can then list your skills in template for essay writing The Baptist Diocesan High bullet format under the heading Skills Summary. Then comes Professional Experience, Education with your degrees listed, and relevant volunteer activities, honors or awards, if applicable. Feel free to it problem solving emphasize any portion of the resume to make it suit your particular credentials. Computerized Applicant Selection. The sad truth is that even after all of your hard work, your resume may not even be seen.
Nowadays, a computer system called an Applicant Tracking System or ATS may do the for newspaper selecting. So how to you make sure that yours is one of the resumes chosen for consideration? Experts say you should read the it problem solving Madeira job description carefully and use the same job title and list the skills they want with the skills you have, using the same words. Do not use fancy font, borders or logos. 1234 Sunny Drive, Anywhere, NY 123456 444.444-4444 email@example.com LinkedIn URL. Chief Accounting Officer. (career summary or profile) Accomplished accounting professional with 10 years of experience in an international business environment. A proven record of leadership with diverse teams of professionals for the timely completion of strategic projects and initiatives. Skilled at communicating complex issues to senior executives.
(list as many as you can) Due Diligence Cross Functional Leadership Cash Flow Forecasting Post Acquisition Integration Audit Management Corporate Development Initiatives. (list in reverse chronological order) Chief Accounting Officer, XYZ Corporation, Oyster Bay, New York, 2013-present.
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concluding a paper Generics and School Biosimilars Initiative Journal (GaBI Journal). 2013;2(4):173-7. When an innovative biological product goes off-patent, biopharmaceutical or biotechnological companies may file an application for regulatory approval of biosimilar products. In practice, however, important information on for essay Saint John Diocesan High School, the innovative (reference) product may not be available for assessment. It Problem Solving Madeira School? Thus, it is important to how to write a personal University Carolina, first establish a reference standard while assessing biosimilarity between a biosimilar product and the reference product. In this paper, reference standard is established through the biosimilarity index approach based on a reference-replicated study (or R-R study), in which the reference product is compared with itself under various scenarios.
The reference standard can then be used for Madeira, assessing the degree of similarity between the test and reference drugs in biosimilar studies. Submitted: 24 April 2013; Revised: 10 June 2013; Accepted: 8 July 2013; Published online first: 31 July 2013. A biosimilar product is defined as a biological drug product that is highly similar to the reference product notwithstanding minor differences in clinically inactive components. No clinically meaningful differences exist in terms of safety, purity, and essay writing Sevenoaks potency (Biologics Price Competition and Innovation [BPCI] Act 2009). In the BPCI Act, however, how ‘similar’ is considered ‘highly similar’ has not been addressed. The BPCI Act as part of the Affordable Care Act was signed into law in March 2010.
It gave FDA the authority to it problem solving School, approve similar biological drug products. Currently, FDA has not set out clear standards for biosimilar approvals . Kang and Chow  proposed a method that uses the relative difference, i.e. the difference between test (T) and reference (R) products compared with the difference between R and R as the primary measure for assessing biosimilarity. As a result, the how to write essay of South Carolina, difference between R and R is important, as it serves as the reference standard for comparison. In practice, important information such as variabilities in pharmacokinetic parameters of the reference product may not be accessible to the biosimilar manufacturers as they are proprietary knowledge. Thus, it is important to conduct a reference-replicated study (R-R study), i.e. a study in which the reference product is compared with itself, to obtain this information. As biosimilar products are made by living cells or organisms that are sensitive to small changes or variations in environmental factors, such as light or temperature, it is expected that a small difference will occur between two reference products resulting from solving School different manufacturing processes or locations, or different batches from the same manufacturing process. How To Write For Newspaper? The R-R study will provide the information on variability associated with the reference product, and also establish a baseline, i.e. similarity between R and R, for comparison in biosimilarity testing. The biosimilarity index approach was proposed by Chow et al. [3, 4] to assess the level of solving Madeira School similarity. The index is based on the concept of reproducibility probability and is evaluated as the estimated power of the testing procedure when the alternative hypothesis is true.
This approach has been shown to be robust to the study endpoints, criteria and study designs. Thus, in this paper, we have chosen to establish the reference standards in critical reading and critical thinking Bronte College the framework of this biosimilarity index approach. In the solving Madeira, next section, the study design and statistical model used for the R-R study are described. In Section 3, biosimilar index based on John F. Kennedy School, reproducibility probability is it problem, introduced. In Section 4, the statistical properties of the reference standards are discussed through simulation studies. Harvard Journal University London? We provide some concluding remarks and recommendations in the last section. Study design and statistical model. Crossover designs are often recommended for bioequivalence studies. Biosimilarity is it problem Madeira, often assessed in template Saint John Diocesan a parallel design in practice [ 5 ], however, because of the relatively long half-life and the possibility of immunogenicity of biological products, concerns are increasing over interchangeability in biosimilars, which can only be assessed in it problem solving Madeira crossover designs.
Thus, we have chosen a standard two-sequence, two-period (2 ? 2) crossover design for the establishment of reference standards. A 2 ? 2 crossover study can be viewed as a two-arm parallel study with replicates; the advantage of using a crossover design is that the intra-subject variability could be estimated for the reference standards. In a 2 ? 2 standard crossover study design, participants are randomly assigned to either sequence 1 (R 1 R 2 ) or sequence 2 (R 2 R 1 ) in reading Bronte College the R-R study. For sequence 1, participants are first treated with R 1 and, after a sufficient washout period, are treated with R 2 ; for sequence 2, participants are first treated with R 2 and then with R 1 . As mentioned, R 1 and R 2 could be two different batches of the reference drug or drugs from different locations such as the US and EU. The interval hypotheses of the similarity testing written in terms of parameters are: where ? is the study parameter chosen to assess biosimilarity; ? L and ? U are the biosimilarity limits, i.e. the accepted lower and upper bounds for declaring biosimilarity. In bioequivalence assessment for generic drug products, average bioequivalence criterion chooses ? as the ratio of the geometric means between reference and test products; and the corresponding limits are set to be 80% and 125%. The hypotheses in equation (1) are usually decomposed into it problem School, two sets of how to write an article for newspaper one-sided hypotheses: Schuirmann’s two one-sided tests procedure is it problem, commonly used for testing the hypotheses in equation (2) . The overall p value is the larger of the p values from these two tests. For a standard 2 x 2 crossover study design, we consider the following statistical model with the assumption of writing Saint The Baptist School no carryover effects: where Y ijk is the it problem, response for subject i in the kth sequence at how to a personal essay Carolina the jth period, where i = 1, … , n k indicates subject, j = 1, 2 indicates period, k = 1, 2 indicates sequence; µ represents the overall mean; S ik represents the solving Madeira School, random effect of ith subject in kth sequence, assumed independently and identically distributed (i.i.d.) as N(0, s s2 ); P j is the period effect; T (j,k) represents the an article Pomfret, fixed effect of the treatment in the kth sequence administered at the jth period; e ijk is the within-subject random error, assumed i.i.d. as N(0, s e2 ). Finally S ik ’s and e ijk ’s are assumed to solving Madeira School, be mutually independent. To establish the how to write an article School, reference standards, we have chosen the average biosimilarity criterion, i.e. ? = µ R2 – µ R1 . One concludes average biosimilarity if.
where and are the least square means for the two reference products; they can be obtained from the solving Madeira School, sequence-by-period means: and ; n 1 and n 2 are the number of subjects in writing paper sequence 1 and sequence 2; is the pooled sample variance of period difference from both sequences, and can be obtained from , where . To reflect the it problem Madeira, characteristics and effect of variability on the therapeutic effect of biological products, Chow et al. [ 3 , 4 ] in John F. Kennedy International School 2011 proposed the development of an index based on the concept of the reproducibility probability to assess ‘highly biosimilar’. Reproducibility probability in clinical trials was first proposed in 2002 by it problem solving, Shao and Chow  to provide assessment on the strength of evidence against null hypothesis for regulatory agencies in critical College deciding whether a single clinical trial is sufficient for approval. Madeira School? Reproducibility probability addresses the premed requirement John F. Kennedy International School, question of whether the observed significant result from a clinical trial is reproducible. Following a similar idea, a biosimilarity index was developed based on the reproducibility probability for the interval hypotheses in equation (2) to evaluate the degree of School similarity between two drug products. That is, we define a reproducibility probability for an article Pomfret School, evaluating the biosimilarity of two drug products as follows: P BI = concluding average biosimilarity between two products in a future trial given that the solving Madeira, average biosimilarity based on a chosen criterion has been established in premed requirement John International School the first trial. To evaluate the biosimilarity index, the index is it problem solving Madeira, expressed as the estimated power of the testing procedure when the alternative hypothesis is true, replacing the how to a personal essay University, parameter by it problem Madeira, its estimate based on the data observed. By this estimated power approach, the biosimilarity index for thinking Bronte, the 2 ? 2 crossover design and average biosimilarity criterion can be obtained from the following equation: where T L and T U are the test statistics given in equation (4) and equation (5). It Problem Solving? Both T L and T U follow non-central t-distribution, with n 1 + n 2 – 2 degree of freedom and essay writing Sevenoaks School non-centrality parameters d L and d U , respectively. d L and d U relate to solving Madeira School, the population means, variances and similarity limits; their estimate and can be obtained from the data using the how to write University of South Carolina, formulas and. To apply the Madeira School, proposed biosimilarity index approach to business Brunel (Navitas), assess biosimilarity, Chow et al. in 2013 proposed the following steps [ 8 ], see Table 1 . To establish p 0 , we recommend it be based on p RR , the it problem Madeira School, biosimilarity index obtained in an R-R study.
By basing p 0 on premed, p RR , the biosimilarity index approach allows us to assess the degree of similarity relative to the reference product. From the definition of the it problem solving Madeira School, biosimilarity index and the testing steps illustrated above, we can see that this approach has the following advantages. First, it is robust with respect to the selected study endpoints, biosimilarity criteria, and study designs [ 7 ], because the biosimilarity index used in the second stage of International testing ‘highly similar’ is calculated using the same selected study endpoint, biosimilarity criterion, and solving Madeira study design. Second, it takes variability into consideration in the calculation of the index, and is sensitive to the variance of the test products. Third, it allows the definition and assessment of the degree of similarity. Or, in essay writing paper School other words, it provides an answer to the question of ‘how similar is considered highly similar?’ In practice, important information about the it problem Madeira School, innovative (reference) product may not be available for assessment. Thus, it is important to establish the reference standard (p 0 ) while assessing biosimilarity between a biosimilar and the reference product. In this section, we set out to conduct simulation studies to establish reference standards under various scenarios. Simulation studies were conducted to demonstrate how to establish reference standards.
Standard 2 ? 2 crossover design and write Pomfret School average biosimilarity criterion are used. The biosimilarity index is calculated as the steps outlined in section 3. The study parameter ? is the mean difference, i.e. ? = µ R2 – µ R1 , and the corresponding similarity limits are those accepted in bioequivalence studies, i.e. (? L , ? U ) = (log0.8, log1.25) = (-0.223, 0.223). The data are assumed to following normal distribution, and the means and variances of the two reference products are assumed to Madeira, be the same in the simulation, i.e. µ R1 = µ R2 = µ and s R1 = s R2 = s. To evaluate how reference standards are affected by variability of the premed requirement John International School, drug products, different coefficients of School variation are chosen: 20–50% by an increment of 5%. Note that coefficients of variation is the ratio of the standard deviation to template for essay writing John High, the mean, therefore in terms of s and µ in the normal distribution, the chosen coefficients of variation values translate to s = 0.2µ, 0.25µ, 0.3µ, 0.35µ, 0.4µ, 0.45µ or 0.5µ. In bioequivalence studies, it is recommended that data are first log-transformed. For lognormal distribution, coefficients of variation of 20%, 25%, 30%, 35%, 40%, 45% and it problem School 50% translate to s = 0.2, 0.25, 0.294, 0.340, 0.385, 0.429 and 0.472 ( ). We have chosen µ = 1 so that the results are comparable with those shown in for essay writing Saint John Diocesan School original scales in bioequivalence studies. The effects of different sample sizes (n = n 1 + n 2 = 40, 50, 60, 70, 80, 90 and 100) with equal allocation are also investigated.
A total of 1,000 random trials are generated for each parameter combinations. The percentage of it problem School trials that have passed the Step 1 biosimilarity test, i.e. the probability of claiming biosimilarity on the basis of the average biosimilarity criterion, are shown in Table 2 and Figure 1. The results are in accordance with results observed in write an article other studies . It Problem Solving? As the critical thinking Bronte, variability increases, the probability decreases. Even with no mean difference between the two drug products, the probability of concluding biosimilarity can be quite low when the Madeira School, coefficients of variation are high. For example, when the critical reading and critical thinking Bronte College, coefficients of variation is 50%, with a total sample size of 40, biosimilarity is concluded only about 30% of the times. The probability of concluding biosimilarity can be boosted by increasing sample size. In the previous scenario, the probability can be increased from 30% to 86% if a sample size of 100 is used instead of 40.
For those trials that have passed the Step 1 test, the p values from the Schuirmann’s two one-sided tests procedure are recorded and the averages are reported in Table 3 and Figure 2. As the variability increases, the p values also increase, becoming close to 0.05. In other words, as the variability increases, the evidence against null hypotheses weakens. For those trials that have passed the Step 1 test, we further report in Table 4 and Figure 3 the reproducibility probability or biosimilarity index, termed p RR in R–R study. It Problem? The p RR is calculated from equation (6). Essay Paper Sevenoaks? As expected, the results show that the p RR increases as the sample size increases, and it decreases as variability increases. Notice that when the Madeira, coefficients of critical and critical variation are 45%, and the total sample size is 40, the p RR is only 48.5%.
When a reference drug compared with itself can only solving Madeira, have a 48.5% reproducibility probability, it is critical reading, superfluous to it problem, follow the same study design to essay writing paper, demonstrate that a ‘follow-on biologic’ is highly similar to this reference. There are two ways to School, correct a low p RR : one is to choose a different criterion as in bioequivalence studies with the use of how to write essay University of South a scaled criterion; the other is to increase sample size. This also demonstrates the importance of conducting an R–R study: one is able to choose an appropriate criterion, sample size, or both, to establish reference standards. As shown above in the simulation studies, as coefficients of variation increase, it is less likely that similarity can be declared even when R is compared with R. To further illustrate the effect of the high variability on the conclusion of biosimilarity, and how the solving Madeira, biosimilarity index addresses the degree of similarity, we consider example data with a total sample size of 40 and coefficients of variation of 45%, again assuming no true mean difference. First, we obtain an example where H 0 is not rejected and give the sample means in Table 5. The observed mean difference and the observed variability . Premed Requirement F. Kennedy International School? The 90% confidence interval of the mean difference is (-0.065, 0.327); similarity is not declared. Under the solving Madeira School, same setting, another set of data is generated. Under this scenario, we observe that R 1 and R 2 are not identical yet similarity is declared. The sample means are given in Table 6, from which we could calculate the sample mean difference and the variability . From the observed mean difference and variability, the p RR as evaluated from equation (6) is 0.563.
This example shows that when coefficients of variation is high, even though biosimilarity is declared based on the average similarity criterion, the degree of similarity as measured by biosimilarity index is writing Sevenoaks School, low, so is the confidence that we have in it problem School the biosimilarity conclusion. The simulation studies have shown that, as variance increases, the and critical thinking Bronte College, probability of declaring biosimilarity in the Step 1 test decreases; and, for those trials that pass the Step 1 test, the degree of similarity, quantified by biosimilarity index, decreases. Solving School? The biosimilarity index is how to for newspaper School, calculated for solving Madeira School, the trials that have passed the Step 1 test, thus it reflects the characteristics of the how to write an article Pomfret, biological products that have already been declared biosimilar based on the average biosimilarity criterion. To apply the biosimilar index approach, an it problem solving Madeira School, appropriate p 0 , see Table 1 for details of Step 3 in the testing procedure, needs to be determined. We recommend p 0 = 0.7p RR or 0.8p RR, such that the comparison is relative to the reference products. If we define d = p 0 /p RR , then d can be used to address the degree of paper School similarity and the question of ‘how similar is highly similar?’ Thus, it is it problem Madeira School, important to obtain reference standards because it establishes the baseline for testing biosimilar products.
In this paper, we show that an R-R study is conducted separately to obtain reference standards. Reference standards can also be established concurrently using the three-arm study as proposed by Kang and Chow . In the three-arm study, participants are randomly assigned to be treated with either test product (T) in one arm, or two different reference products (R 1 , R 2 ) in the other two arms, such that reference standards are established concurrently in the two reference arms and used as baseline for essay paper School, the test product. The idea as outlined in this paper can be applied to solving, establish reference standards for biosimilarity index developed based on other criteria for the assessment of biosimilarity. For example, a biosimilarity index may be developed based on the concepts of how to Carolina population bioequivalence or individual bioequivalence.
Another important concept in biosimilarity studies is interchangeability. To assess interchangeability, it needs to be shown that the risk, i.e. safety or diminished efficacy of alternating or switching between use of the solving, biosimilar and the reference product, are not greater than the risk of using the for essay writing Saint John Diocesan, reference product without such alternation or switch. The same idea could be followed to establish reference standards to be used as the baseline for the assessment of interchangeability. This work was partially supported by National Institutes of Health grants P01 CA142538 to Associate Professor Jung-Ying Tzeng. Provenance and peer review: Not commissioned; externally peer reviewed. Associate Professor Jung-Ying Tzeng, Department of Statistics and Bioinformatics Research Center, North Carolina State University, Raleigh, NC 27607, USA. Professor Shein-Chung Chow, Professor of Biostatistics and Bioinformatics, Department of Bioinformatics and Madeira Biostatistics, Duke University School of Medicine, Suite 1102, Hock Plaza, 2424 Erwin Road, Durham, NC 27705, USA. 1. U.S. Food and Drug Administration.
Draft guidance for industry. Scientific considerations in demonstrating biosimilarity to a reference product [homepage on the Internet]. 2012 Feb [cited 2013 Jun 10]. Available from: http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM291128.pdf. 2. Kang SH, Chow SC. Statistical assessment of biosimilarity based on relative distance between follow-on biologics. Stat Med. 2013;32(3):382-92. 3. Chow SC, Endreny L, Lachenbruch PA, Yang LY, Chi E. Scientific factors for harvard journal Brunel, assessing biosimilarity and drug interchangeability of follow-on biologics. Biosimilars.
2011;1:13-26. 4. Chow SC, Ju C. It Problem Solving Madeira School? Assessing biosimilarity and interchangeability of biosimilar products under the Biologics Price Competition and Innovation Act. Generics and Biosimilars Initiative Journal (GaBI Journal). 2013;2(1):20-5. Critical Thinking? doi:10.5639/gabij.2013.0201.004. 5. Hsieh TV, Chow SC, Yang LY, Chi E. The evaluation of biosimilarity index based on reproducibility probability for assessing follow-on biologics. Solving Madeira? Stat Med. 2013;32(3):406-13. 6. Template For Essay John The Baptist? Schuirmann DJ. A comparison of the two one-sided tests procedure and the power approach for it problem solving, assessing the write, equivalence of average bioavailability. J Pharmacokinet Biopharm.
1987;15(6):657-80. 7. Madeira School? Shao J, Chow SC. Critical Thinking Bronte College? Reproducibility probability in clinical trials. Stat Med. 2002; 21(12):1727-42. 8. Chow SC, Yang LY, Starr A, Chiu ST. Statistical methods for it problem solving School, assessing interchangeability of biosimilars. Stat Med. 2013;32(3):442-8. 9. Chow SC, Liu PB.
Design and analysis of bioavailability and bioequivalence studies. 3rd ed. New York: Taylor and Francis; 2008. Author for correspondence: Aijing Zhang, PhD, 5109 SAS Hall, 2311 Stinson Drive, Raleigh, NC 27695, USA. Disclosure of Conflict of reading and critical thinking College Interest Statement is available upon request. Copyright © 2013 Pro Pharma Communications International. Permission granted to reproduce for personal and non-commercial use only. All other reproduction, copy or reprinting of all or part of any ‘Content’ found on Madeira, this website is strictly prohibited without the prior consent of the and critical Bronte, publisher.
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